Small Animal Imaging

MRI/MRS for the study of disease and metabolism

Research in neuroscience now relies heavily on animal MRI/MRS where in many instances it has now been established as the gold standard. Other major applications areas include cardiovascular, respiratory and gastro-intestinal studies together with research into arthritis, oncology and metabolic disorders. Over the past decades magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) have shown enormous utility for research applications in the life sciences. Functional MRI (fMRI) is probably the most spectacular application and as yet has still to be fully exploited, especially by neuroscientists. The latest developments in molecular biology and genome research have recently led to an expansion in the use of animal MRI/MRS applications. Molecular imaging and rapid phenotyping of transgenic animals are two such applications that have extended the role of MRI/MRS in pharmacology.
 

High Resolution Neuroanatomy

High Resolution Anatomy

Using implanted coils, MR images with spatial 3D resolution of 50 x 50 x 1000 µm3 can be obtained in the visual cortex.

Multi modality imaging

MRI and µSPECT

Multi modality imaging using MRI and µSPECT

Infarct Study Mouse

Infarct Study on the Mouse Heart

Infarcted and control animals were scanned with magnitude images and phase contrast-based vectormaps.